NHS-PEG4-SS-PEG4-NHS is a cleavable linker with two NHS esters connected by a disulfide bond and PEG4 spacers. The NHS esters efficiently bind to primary amines, forming stable amide bonds, while the disulfide bond allows cleavage under reducing conditions for controlled release.
Key Features:
- NHS Ester Groups: Bind efficiently to primary amines for stable conjugation.
- Disulfide Bond (SS): Enables controlled release under reducing conditions.
- PEG4 Spacer: Increases solubility and reduces steric hindrance.
Applications:
- Antibody-Drug Conjugates (ADCs): Links drugs to antibodies for targeted therapy.
- Protein and Peptide Conjugation: Attaches proteins or peptides to molecules or surfaces.
- Surface Functionalization: Adds functional groups for biosensor development.
Store at -20°C and dissolve in DCM, THF, acetonitrile, DMF, or DMSO for use.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
