NHS-PEG2-SS-PEG2-NHS is a cleavable linker with two NHS esters connected by a disulfide bond and PEG2 spacers. The NHS esters bind to primary amines, forming stable amide bonds, while the disulfide bond enables cleavage under reducing conditions for controlled release. The PEG2 units enhance solubility and flexibility, minimizing steric hindrance.
Key Features:
- NHS Ester Groups: Bind efficiently with primary amines for stable conjugation.
- Disulfide Bond (SS): Allows controlled release under reducing conditions.
- PEG2 Spacers: Increase solubility and reduce steric hindrance.
Applications:
- Antibody-Drug Conjugates (ADCs): Links drugs to antibodies for targeted therapy.
- Protein and Peptide Conjugation: Attaches proteins or peptides to surfaces.
- Surface Functionalization: Adds functional groups to surfaces for biosensors.
Store at -20°C and dissolve in DCM, THF, acetonitrile, DMF, or DMSO.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
