N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite (also known as 2′-O-Propargyl G(iBu)-3′-phosphoramidite, CAS 171486-61-6) is a specialized phosphoramidite designed for modified RNA oligonucleotide synthesis. Containing both propargyl and isobutyryl protection groups, it readily attaches to diverse biomolecules. The reactive 2′-O-propargyl unit enables conjugation with azide-linked compounds through click chemistry, providing versatile molecular binding options for conjugation.
Key Features:
- CAS Number: 171486-61-6
- Other Names: 2′-O-Propargyl G(iBu)-3′-phosphoramidite
- Chemical Structure: N2-isobutyryl-protected guanosine with propargyl and DMTr groups
- Function: Building block for RNA oligonucleotide synthesis, optimized for click chemistry
- Protection Groups: Isobutyryl on guanosine’s exocyclic amine, DMTr for 5′ hydroxyl, propargyl at 2′-O position
- Applications:
- RNA oligonucleotide synthesis
- Click chemistry conjugation with azide-linked compounds
- Therapeutic research and advanced biomolecular binding
N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite allows for efficient RNA synthesis and bio-orthogonal conjugation, making it ideal for creating modified oligonucleotides in research and therapeutic applications.
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