N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite
This product is a modified guanosine phosphoramidite with N2-isobutyryl, DMTr protection, and a 2’-O-propargyl group. It specifically enables oligonucleotide synthesis, site-specific modifications, and conjugation.
Key Features and Benefits
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N2-Isobutyryl Protection: Preserves guanosine base integrity during oligonucleotide synthesis.
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DMTr Group: Provides temporary protection for 5’-hydroxyl functionality.
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2’-O-Propargyl Group: Introduces a clickable alkyne handle for conjugation.
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CED Phosphoramidite: Ensures compatibility with automated DNA/RNA synthesis.
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High Purity: Guarantees reproducibility in nucleic acid synthesis.
Applications
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Oligonucleotide Synthesis: Incorporates modified guanosine into DNA or RNA sequences.
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Bioconjugation: Enables click chemistry through 2’-O-propargyl group.
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Probe Development: Builds labeled nucleic acids for imaging and diagnostics.
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Therapeutics: Supports nucleic acid–based drug design and delivery research.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use under anhydrous conditions; avoid prolonged air or moisture exposure.
This product integrates standard guanosine protections with a propargyl handle, specifically enabling oligonucleotide synthesis and site-specific conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
