N2-iBu-5′-O-DMTr-2′-O-hexadecanyl guanosine 3′-CED phosphoramidite (CAS: 2382942-32-5)
N2-iBu-5′-O-DMTr-2′-O-hexadecanyl guanosine 3′-CED phosphoramidite is a specialized reagent for oligonucleotide synthesis. It combines an N2-isobutyryl (iBu) group for protection, a 5′-O-DMTr group for efficient coupling, and a 2′-O-hexadecanyl modification to improve lipophilicity and stability. This reagent works well in solid-phase synthesis, offering high efficiency and precise control.
Key Features:
- N2-iBu Protection: Protects guanosine during synthesis for better stability.
- 5′-O-DMTr Group: Ensures efficient coupling and easy deprotection.
- 2′-O-Hexadecanyl: Increases lipophilicity, making it more stable and versatile.
- 3′-CED Phosphoramidite: Supports fast, efficient oligonucleotide synthesis.
Applications:
- Oligonucleotide Synthesis: Ideal for creating stable, modified oligonucleotides.
- Nucleic Acid Research: Useful in research needing stable, lipophilic oligonucleotides.
- Gene Synthesis: Great for producing gene sequences with enhanced properties for biological use.
Advantages:
- High Efficiency: Maximizes yield and quality in oligonucleotide production.
- Enhanced Stability: Improves oligonucleotide stability for diverse applications.
- Selective Protection: Allows controlled synthesis with efficient protection and deprotection steps.
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