N-(Propargyl-PEG4)-biocytin
This product is a biotin derivative containing a PEG4 spacer and a terminal propargyl (alkyne) group. The biotin moiety provides strong binding to streptavidin/avidin, while the alkyne enables bioorthogonal click chemistry with azides, making it ideal for targeted labeling and multifunctional bioconjugation.
Key Features and Benefits:
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Biotin Moiety: Ensures high-affinity binding to streptavidin and avidin systems.
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Propargyl Group: Supports CuAAC and SPAAC click chemistry with azides.
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PEG4 Spacer: Enhances solubility and reduces steric hindrance in conjugation.
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High Purity: Provides reproducible performance in labeling workflows.
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Dual Reactivity: Combines affinity capture with click-enabled conjugation.
Applications:
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Affinity Labeling: Biotinylation of proteins, peptides, and other biomolecules.
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Click Chemistry: Propargyl–azide conjugation for dual labeling strategies.
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Drug Delivery: Biotin-mediated targeting combined with orthogonal payload conjugation.
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Surface Modification: Functionalize biosensors, nanoparticles, or hydrogels.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use freshly prepared anhydrous solvents (e.g., DMF, DMSO) to maintain alkyne reactivity.
This product provides high-affinity biotin binding with click-ready alkyne functionality, making it an especially versatile linker for advanced conjugation and targeted labeling.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
