N-(t-Boc-N-Amido-PEG4)-NH-PEG4-t-butyl ester
This product is a high-purity PEG linker with a t-Boc-protected amine, an amide linkage, and a t-butyl-protected acid. Dual PEG4 spacers specifically improve solubility, flexibility, and reduce steric hindrance. After deprotection, the amine couples with acids and the acid with amines, especially ideal orthogonal, multi-step bioconjugation and material modification.
Key Features and Benefits
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t-Boc-Protected Amine: Allows controlled deprotection for selective amine coupling.
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t-Butyl-Protected Carboxylic Acid: Enables mild acidic deprotection to yield a reactive acid group.
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Dual PEG4 Spacers: Enhance solubility, flexibility, and accessibility of reactive groups.
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Amide Linkage: Provides stability and defined spacing between functional domains.
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High Purity: Supplied at >95% purity for reproducible results.
Applications
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Orthogonal and site-specific conjugation strategies.
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Protein, peptide, and small molecule modification.
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Surface and nanoparticle functionalization.
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Multi-step synthesis of complex bioconjugates.
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PEGylation in drug delivery and diagnostics.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain protection group stability.
N-(t-Boc-N-Amido-PEG4)-NH-PEG4-t-butyl ester provides both amine and acid functionalities in protected form, linked by dual PEG4 spacers for solubility and flexibility specifically in orthogonal, multi-step bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.