N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid (CAS: 2183440-70-0) is a multifunctional PEG linker with three reactive groups: an azide for click chemistry, an amine for nucleophilic reactions, and a carboxylic acid for amide bond formation. Its PEG spacers improve water solubility and flexibility, making it highly versatile in bioconjugation and molecular assembly.
Key Features:
- Functional Groups:
- Azide: For CuAAC (click chemistry) with alkynes
- Amine: For coupling with activated esters or electrophiles
- Carboxylic Acid: For amide bond formation with primary amines
- Molecular Formula: C₁₉H₃₈N₄O₁₀
- Molecular Weight: 466.53 g/mol
- Purity: Typically ≥95%
Applications:
- Bioconjugation: Links biomolecules through click chemistry, amine coupling, and amide bond formation.
- Antibody-Drug Conjugates (ADCs): Acts as a stable linker for attaching drugs to antibodies.
- Surface Functionalization: Functionalizes surfaces with reactive groups for biosensor and bioassay development.
This versatile linker supports targeted drug delivery, diagnostics, and chemical biology research, offering flexible and efficient conjugation options.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
