N-(5-Aminopentyl)maleimide hydrochloride
This product is a bifunctional linker containing a maleimide group and a terminal primary amine on a pentyl chain. It enables selective thiol coupling and amine-based conjugation, specifically offering orthogonal reactivity in a compact and soluble scaffold.
Key Features and Benefits
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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Primary Amine: Reacts with carboxyls, NHS esters, or activated linkers.
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Pentyl Chain: Provides flexibility and spacing between reactive groups.
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Hydrochloride Salt: Enhances solubility and handling.
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High Purity: Ensures reproducibility in bioconjugation workflows.
Applications
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Bioconjugation: Links thiol-containing biomolecules with carboxyl- or NHS-modified partners.
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Probe Development: Builds multifunctional probes with orthogonal reactivity.
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Drug Delivery: Provides scaffolds with dual conjugation handles.
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Material Science: Functionalizes polymers and nanoparticles with thiol and amine groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product combines thiol-selective maleimide chemistry with amine reactivity in a compact scaffold, specifically offering versatile dual-functionality for conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
