N-(2-Hydroxyethyl)maleimide
N-(2-Hydroxyethyl)maleimide is a high-purity maleimide derivative featuring a reactive maleimide group for thiol-specific Michael addition and a terminal hydroxyl group for further derivatization. The hydroxyl functionality enables esterification, ether formation, or activation to reactive intermediates, while the maleimide provides rapid and selective conjugation to cysteine residues under mild conditions. This combination makes it ideal for protein modification, polymer crosslinking, and bioconjugation strategies.
Key Features and Benefits
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Maleimide Group: Enables fast, selective thiol conjugation.
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Hydroxyl Group: Allows further chemical modification and functionalization.
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Versatile Applications: Suitable for bioconjugation, drug delivery, and material surface modification.
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Mild Reaction Conditions: Compatible with aqueous and physiological environments.
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High Purity: Ensures reproducibility in sensitive applications.
Applications
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Protein and peptide labeling through cysteine residues.
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Synthesis of functionalized polymers and hydrogels.
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Surface modification for biosensors and biomaterials.
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Drug delivery system development with thiol-reactive linkers.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use in anhydrous conditions when possible; avoid prolonged exposure to moisture.
This maleimide-hydroxyl bifunctional linker offers thiol-specific conjugation with an additional handle for orthogonal modification, making it highly adaptable for protein labeling, crosslinking, and advanced material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
