Methyltetrazine-PEG8-NH-Boc is a versatile and highly functionalized bioconjugation molecule. It comprises a methyltetrazine moiety, a polyethylene glycol (PEG8) linker, and a tert-butyloxycarbonyl (Boc) protected amine. The methyltetrazine group enables rapid bioorthogonal click reactions, the PEG8 linker imparts water solubility and reduces immunogenicity, while the Boc group allows for straightforward amine deprotection and conjugation to biomolecules.
Methyltetrazine-PEG8-NH-Boc serves as a valuable tool in pharmaceutical research and development, particularly in the field of targeted drug delivery. It facilitates the site-specific attachment of therapeutic agents to biomolecules, such as antibodies or peptides, through bioorthogonal click chemistry. This targeted conjugation enables the design of antibody-drug conjugates (ADCs) and peptide-drug conjugates (PDCs), which have shown promise in enhancing drug efficacy, reducing off-target effects, and improving the pharmacokinetic properties of various therapeutic compounds.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
