Mal-PEG4-Lys(t-Boc)-NH-m-PEG24 is a high-quality and efficient reagent designed for bioconjugation applications in pharmaceutical research and development. This bifunctional PEG (polyethylene glycol) derivative features a maleimide (Mal) functional group at one end, which selectively reacts with thiol-containing molecules such as cysteine residues in proteins or peptides. The other end of the molecule contains a monomethyl-terminated PEG24 (m-PEG24) chain, providing water solubility, reduced immunogenicity, and increased stability to the conjugated biomolecules.
The central lysine residue in Mal-PEG4-Lys(t-Boc)-NH-m-PEG24 is protected by a t-Boc (tert-butyloxycarbonyl) group, which can be easily removed under mild acidic conditions, exposing a primary amine for further conjugation. This versatile reagent enables the creation of diverse bioconjugates, including protein-drug conjugates, antibody-drug conjugates, and PEGylated biomolecules, which are widely employed in the development of innovative therapeutics and diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.