Mal-PEG4-bis-PEG3-methyltetrazine is a dual-functional PEG linker designed for precise bioconjugation and chemical biology. It features a maleimide group for thiol-specific conjugation and methyltetrazine groups for fast and selective bioorthogonal ligation with TCO (trans-cyclooctene) via inverse electron demand Diels-Alder (IEDDA) reactions. Its PEG4 and bis-PEG3 linkers enhance solubility and flexibility, ensuring efficient performance in aqueous and biological systems.
Key Features
- Dual Reactivity:
- Maleimide: Forms stable thioether bonds with thiol groups (-SH).
- Methyltetrazine: Reacts quickly and selectively with TCO groups for bioorthogonal labeling.
- Enhanced Solubility:
- The PEG4 and bis-PEG3 linkers improve water solubility and reduce steric hindrance.
- Biocompatibility:
- Non-toxic and suitable for live-cell and in vivo applications.
Applications
- Bioconjugation:
- Attaches peptides, proteins, and nucleic acids using thiol and methyltetrazine chemistry.
- Ideal for creating complex, dual-functional biomolecules.
- Drug Delivery:
- Serves as a linker in targeted drug delivery systems, improving stability and bioavailability.
- Nanotechnology:
- Functionalizes nanoparticles, biosensors, and medical devices for bioorthogonal labeling.
- Chemical Biology:
- Enables specific, copper-free labeling and crosslinking in live-cell and in vivo experiments.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
