Mal-PEG3-oxyamine
Mal-PEG3-oxyamine is a high-purity heterobifunctional PEG linker with a maleimide group for thiol-specific conjugation and an oxyamine group for chemoselective coupling with aldehydes or ketones via oxime bond formation. The PEG3 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. This design is ideal for orthogonal strategies requiring sequential thiol and carbonyl conjugation.
Key Features and Benefits
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds.
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Oxyamine Group: Reacts with aldehydes and ketones to form stable oxime linkages under mild conditions.
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PEG3 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Enables orthogonal and sequential modification strategies.
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High Purity: Supplied at >95% purity for reproducible and consistent results.
Applications
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Stepwise Bioconjugation: Conjugate thiols first, then link to carbonyl-containing molecules.
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Protein and Peptide Modification: Add carbonyl-reactive oxyamine handles to thiol-bearing biomolecules.
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Nanoparticle and Surface Functionalization: Equip surfaces with both thiol and carbonyl reactivity.
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Drug Delivery Systems: Build multifunctional linkers for controlled payload attachment.
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Diagnostic and Imaging Probes: Create dual-functional probes with orthogonal chemistries.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to maintain reactivity.
Mal-PEG3-oxyamine combines thiol reactivity with carbonyl coupling capability in a hydrophilic PEG3 framework, offering versatility for orthogonal bioconjugation in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
