Mal-PEG2-Val-Cit-PAB-OH
This product is a cleavable PEG2 linker featuring a maleimide for thiol conjugation, a Val-Cit dipeptide for protease-triggered cleavage, and a PAB self-immolative spacer with a terminal hydroxyl. This design makes it especially used in antibody–drug conjugates (ADCs) and targeted drug delivery systems.
Key Features and Benefits:
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Maleimide Group: Enables site-specific thiol conjugation to cysteine residues.
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Val-Cit Dipeptide: Cleaved by cathepsin B and lysosomal enzymes for controlled drug release.
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PAB Spacer: Self-immolative unit ensuring traceless payload release.
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PEG2 Spacer: Provides solubility and flexibility for conjugation.
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High Purity: Optimized for sensitive ADC and bioconjugation workflows.
Applications:
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Antibody–Drug Conjugates (ADCs): Gold-standard cleavable linker for targeted drug delivery.
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Bioconjugation: Enables stable conjugation and controlled payload release.
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Drug Delivery: Improves pharmacokinetics and therapeutic index of payloads.
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Research Use: Model linker in ADC development and validation studies.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to maintain reactivity.
This product combines maleimide thiol conjugation with protease-cleavable Val-Cit-PAB chemistry, making it a cornerstone linker specifically for advanced ADC and targeted drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
