Mal-PEG2-Oxyamine (Aminooxy-PEG2-Mal)
CAS: 1146245-73-9
Description:
Mal-PEG2-Oxyamine is a bifunctional linker with a maleimide group and an aminooxy (oxyamine) group connected by a PEG2 (polyethylene glycol) spacer. The maleimide group specifically reacts with thiol groups, while the aminooxy group selectively binds to carbonyl groups (aldehydes or ketones) through oxime ligation. This structure provides flexibility and solubility, making it ideal for bioconjugation applications in research.
Key Features:
- Maleimide Group: Reacts specifically with thiol groups, allowing covalent attachment to cysteine residues in proteins.
- Aminooxy Group: Binds to carbonyl-containing groups (aldehydes/ketones), enabling oxime formation for stable conjugation.
- PEG2 Spacer: Enhances solubility and flexibility, minimizing steric hindrance in conjugation.
Applications:
- Bioconjugation: Links biomolecules with thiol and carbonyl groups, useful in protein and peptide modifications.
- Drug Delivery: Allows precise attachment of therapeutic molecules to biomolecules for targeted delivery.
- Protein and Antibody Labeling: Ideal for modifying proteins with accessible thiol and carbonyl groups for imaging and therapeutic studies.
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