Mal-PEG2-bis-PEG2-BCN is a versatile bi-functional PEG linker designed for advanced bioconjugation and chemical biology applications
Chemical Information
- Structure: Contains a maleimide group for thiol-specific conjugation, a bis-PEG2 linker for added solubility, and a BCN (bicyclononyne) group for strain-promoted azide-alkyne cycloaddition (SPAAC).
Key Features
- Dual Functional Groups:
- Maleimide: Reacts with thiol groups (-SH) to form stable thioether bonds.
- BCN: Enables copper-free bioorthogonal reactions with azides.
- PEG Linker:
- PEG2 and bis-PEG2 provide flexibility, water solubility, and reduced steric hindrance.
- Biocompatible:
- Non-toxic and suitable for use in biological environments.
Applications
- Bioconjugation:
- Links biomolecules like peptides, proteins, or nucleic acids through thiol and azide groups.
- Facilitates complex systems requiring dual functionalization.
- Drug Delivery:
- Serves as a linker for drug conjugates, improving solubility and bioavailability.
- Nanotechnology:
- Functionalizes nanoparticles and surfaces for bioorthogonal labeling and targeting.
- Chemical Biology:
- Enables bioorthogonal crosslinking and labeling in live-cell and in vivo studies.
Storage and Handling
- Storage: Store at -20°C in a dry, tightly sealed container, away from light and moisture.
- Handling: Use protective equipment and work in a dry environment to preserve reactivity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
