Mal-PEG1-Val-Cit-OH
This product is a cleavable heterobifunctional linker containing a maleimide group, a short PEG1 spacer, a Val-Cit dipeptide, and a terminal hydroxyl group. The maleimide reacts selectively with thiols to form stable thioether bonds, while the Val-Cit sequence is cleaved by cathepsin B inside tumor cells. The PEG1 spacer specifically provides minimal flexibility and solubility, and the terminal hydroxyl group serves as a handle for further functionalization.
Key Features and Benefits
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Maleimide Group: Selectively couples with thiols to form stable thioether linkages.
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Val-Cit Linker: Protease-sensitive dipeptide sequence cleaved by cathepsin B.
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PEG1 Spacer: Adds compact solubility and reduces steric hindrance.
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Terminal Hydroxyl: Allows further chemical modification or payload attachment.
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High Purity: Produced to ≥95% purity for consistent performance.
Applications
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Antibody–Drug Conjugates (ADCs): Provides a cleavable maleimide linker for controlled drug release.
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Drug Delivery: Builds protease-sensitive delivery systems.
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Probe Development: Supports design of cleavable probes for imaging and diagnostics.
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Bioconjugation: Serves as an intermediate for linker–payload constructs.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Dissolve freshly before use; avoid repeated freeze–thaw cycles.
This product combines thiol-reactive maleimide chemistry with a cathepsin B-cleavable dipeptide and hydroxyl functionality, making it an especially versatile tool for ADC research and controlled bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
