The maleimide group in Mal-PEG1-Val-Ala-PAB-PNP CAS:1912408-50-4 is a highly reactive thiol-specific group that can react with cysteine residues in proteins and peptides to form covalent bonds. This property makes maleimide-based linkers useful in the conjugation of proteins, peptides, and other biomolecules for various applications in biotechnology and drug discovery.
The PEG chain in Mal-PEG1-Val-Ala-PAB-PNP can improve the solubility, stability, and biocompatibility of drugs, as well as provide a spacer that can reduce steric hindrance and increase the accessibility of the maleimide group.
The dipeptide and PAB groups in Mal-PEG1-Val-Ala-PAB-PNP can be used to target specific cells or tissues by exploiting the activity of peptidases, which are enzymes that cleave specific peptide sequences. These groups can be selectively cleaved by peptidases in tumor cells, allowing for targeted drug delivery and improved therapeutic efficacy.
the PNP leaving group in Mal-PEG1-Val-Ala-PAB-PNP can be used to facilitate the release of the drug from the linker by enzymatic cleavage. This controlled release mechanism can improve the drug’s efficacy and reduce its toxicity, making it a promising candidate for targeted drug delivery in various diseases.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
