Mal-amido-PEG8-Val-Gly-PAB-OH
This product is a cleavable linker with a maleimide for thiol conjugation, a Val–Gly dipeptide for protease sensitivity, and a PAB self-immolative spacer. The PEG8 chain improves solubility, flexibility, and spacing, making it especially effective for ADC development and targeted bioconjugation.
Key Features and Benefits:
-
Maleimide Group: Couples selectively to thiols for stable cysteine conjugation.
-
Val–Gly Dipeptide: Cleaved by proteases to trigger payload release.
-
PAB Spacer: Self-immolative unit ensures efficient drug liberation.
-
PEG8 Spacer: Enhances solubility, hydrophilicity, and steric spacing.
-
High Purity: Provides reproducibility in conjugation and drug delivery workflows.
Applications:
-
ADC Development: Used for designing cleavable antibody–drug conjugates.
-
Drug Delivery: Enables protease-triggered release in tumor environments.
-
Bioconjugation: Supports thiol-to-payload assembly with controlled cleavage.
-
Probe Design: Useful in protease-cleavable imaging or diagnostic probes.
Storage and Handling:
-
Storage: Store at –20 °C in a tightly sealed, light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve reactivity.
This product combines thiol reactivity, protease-cleavable functionality, and self-immolative release in a long PEG scaffold, making it an especially versatile linker for ADCs and targeted conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
