(E/Z)-4-Hydroxytamoxifen is an active metabolite of tamoxifen, used in estrogen receptor (ER) research. It exists in both (E) and (Z) isomers, each with distinct biological activities. As a selective estrogen receptor modulator (SERM), it is vital in breast cancer treatment and research.
Mal-amido-PEG4 NHS ester Key Features:
- (E/Z) Isomers: The compound exists in both (E) and (Z) forms. Each isomer affects estrogen receptor binding differently.
- SERM Activity: It acts as an antagonist in breast tissue and as an agonist in bone and uterus. This dual action makes it valuable for therapy.
- Anticancer Activity: As a metabolite of tamoxifen, it is crucial in estrogen receptor-positive breast cancer research and treatment.
- High Purity: It ensures consistent results, making it suitable for both in vitro and in vivo applications.
- Solubility: It dissolves in various solvents, offering flexibility in experimental setups.
Mal-amido-PEG4 NHS ester Applications:
- Breast Cancer Research: (E/Z)-4-Hydroxytamoxifen is essential for studying tamoxifen’s effect on estrogen receptor-positive breast cancer.
- Hormone-Related Diseases: It also investigates estrogen signaling in disorders like endometriosis and polycystic ovary syndrome (PCOS).
- Cellular Signaling Studies: Furthermore, it helps study estrogen receptor-mediated pathways and gene expression.
- Drug Development: It plays a key role in developing SERM-based therapies for cancer and other diseases.
- Endocrine Disruption Research: Additionally, it helps study selective estrogen receptor modulators’ effects on endocrine systems.
Conclusion:
In conclusion, (E/Z)-4-Hydroxytamoxifen (CAS: 756525-99-2) is crucial in estrogen receptor research. Its dual isomeric forms and selective modulation of estrogen receptors make it indispensable for breast cancer studies, hormone-related disorders, and drug development. With high purity and solubility, it is versatile for scientific applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
