Mal-amido-PEG2 NHS ester CAS:955094-26-5 is a high-performance, water-soluble crosslinking reagent designed for conjugating various biomolecules in pharmaceutical research and development. This bifunctional linker features a maleimide group at one end and an N-hydroxysuccinimide (NHS) ester at the other, enabling selective attachment to thiol- and amine-containing molecules, respectively.
The maleimide group reacts specifically with sulfhydryl groups on cysteine residues, forming stable thioether bonds. The NHS ester moiety reacts efficiently with primary amines, typically found in lysine side chains, generating stable amide linkages. The PEG2 spacer imparts hydrophilicity, minimizing aggregation and increasing solubility of conjugated biomolecules.
This reagent is widely utilized in pharmaceutical R&D for various applications such as the synthesis of antibody-drug conjugates (ADCs), site-specific protein labeling, and the preparation of bioactive peptides and polymers. Additionally, it is employed in the development of targeted drug delivery systems and theranostic agents, enhancing their pharmacokinetic profiles and biodistribution properties.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
