Mal-Amido-PEG12 NHS Ester (CAS: 2101722-60-3) offers a significantly powerful solution for bioconjugation, drug delivery, and material science applications. It combines a maleimide group for thiol reactivity, an NHS ester for amine coupling, and a 12-unit PEG spacer for flexibility and solubility. Furthermore, this unique combination ensures high performance in a wide range of biomedical applications.
Key Features
- Molecular Formula: C₂₉H₄₄N₂O₁₅
- Molecular Weight: Approximately 660 g/mol
- Functional Groups:
- Maleimide for targeted thiol reactions
- NHS ester for efficient amine coupling
- PEG12 spacer to significantly improve solubility and minimize steric hindrance
Applications
1. Bioconjugation
Mal-Amido-PEG12 NHS Ester simplifies the process of attaching biomolecules. The maleimide group reacts specifically with thiol groups, while the NHS ester forms stable amide bonds with primary amines. This versatility makes it significantly ideal for labeling proteins, peptides, or antibodies with precision.
2. Drug Delivery
The PEG12 spacer enhances solubility and reduces the immune response to conjugated molecules. Its flexibility allows for stable drug delivery systems that improve bioavailability and therapeutic effectiveness.
3. Material and Surface Functionalization
This reagent works well for modifying surfaces or nanoparticles. The PEG spacer reduces non-specific binding and provides a flexible linkage, enabling the design of advanced materials and biosensors.
Handling and Storage
Store Mal-Amido-PEG12 NHS Ester at −20°C in a dry, inert atmosphere to maintain its reactivity. Protect it from light and moisture, and use promptly after opening to ensure optimal performance.
Overall, this product delivers reliable performance in bioconjugation, drug delivery, and surface modification. Additionally, its maleimide and NHS ester groups ensure efficient and selective reactions, while the PEG12 spacer adds solubility and flexibility, making it a versatile choice for biomedical research and material science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
