m-PEG9 NHS succinate

m-PEG9 NHS Succinate (CAS: 2353409-76-2)

m-PEG9 NHS Succinate offers a reliable solution for bioconjugation, surface modification, and drug delivery. This compound features a 9-unit polyethylene glycol (PEG) spacer with a methoxy end and a reactive succinimidyl ester (NHS) group. Its excellent solubility, biocompatibility, and reactivity with primary amines make it a preferred choice for various biomedical applications.

Key Features

• Molecular Formula: C₂₁H₃₉NO₁₁
• Molecular Weight: 481 g/mol
• Functional Groups:
  • Methoxy (m-PEG) end for hydrophilicity
  • Succinimidyl ester (NHS) for efficient amine coupling
• Form: White to off-white solid

Applications

Bioconjugation

m-PEG9 NHS Succinate reacts efficiently with primary amines, forming stable amide bonds. Additionally, this functionality makes it ideal for attaching proteins, peptides, or other biomolecules in drug development and diagnostic projects.

Surface Modification

When used for surface modifications, this compound significantly improves hydrophilicity and minimizes non-specific binding. It works particularly well on nanoparticles, biosensors, and other interfaces requiring a biocompatible layer.

Drug Delivery

The 9-unit PEG spacer adds solubility and steric stabilization, which enhances the stability and performance of drug delivery systems. It also facilitates the attachment of therapeutic agents or targeting molecules for precision applications.

Handling and Storage

To maintain its reactivity, store m-PEG9 NHS Succinate at −20°C in a dry, inert environment. Keep it away from moisture and use promptly after opening for the best results.

Overall, this product delivers exceptional performance in bioconjugation, surface functionalization, and drug delivery. With its NHS group for efficient amine coupling and a PEG spacer for flexibility and solubility, it stands out as a significantly versatile tool in biomedical research and development.