m-PEG5-t-butyl ester
This product is a monofunctional PEG derivative featuring a methoxy group at one end, a PEG5 spacer, and a tert-butyl ester group at the other end. The tert-butyl ester serves as a protected carboxyl group that can be selectively deprotected under acidic conditions, specifically enabling controlled conjugation. The PEG5 chain provides solubility, flexibility, and hydrophilicity, making this reagent especially useful in bioconjugation and drug delivery.
Key Features and Benefits
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Methoxy End-Cap: Provides stability and prevents undesired crosslinking.
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t-Butyl Ester: Protects a carboxyl group for orthogonal deprotection.
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PEG5 Spacer: Improves solubility, flexibility, and accessibility.
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Orthogonal Design: Supports stepwise functionalization strategies.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Provides a protected carboxyl handle for controlled coupling.
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Drug Delivery: Serves as a PEGylation reagent for therapeutic development.
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Probe Development: Builds intermediates for imaging and diagnostic tools.
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Polymer Modification: Introduces PEG units into functional polymer systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Remove t-butyl ester under mild acidic conditions; prepare fresh solutions.
This product combines a protected ester and methoxy capping in a PEG5 scaffold, specifically offering stability and versatility for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
