m-PEG4-TCO is a PEG-based linker with a methoxy group on one end and a trans-cyclooctene (TCO) group on the other. Its PEG4 spacer enhances solubility, stability, and biocompatibility, making it ideal for biomedical applications like drug delivery and bioconjugation.
Key Features:
- Methoxy Termination: Increases stability and reduces unwanted interactions in biological systems.
- TCO Group: Enables rapid and specific bioorthogonal reactions with tetrazine-containing compounds via strain-promoted inverse electron demand Diels-Alder (SPIEDAC) cycloaddition.
- PEG4 Spacer: Improves solubility, reduces immunogenicity, and enhances pharmacokinetics.
m-PEG4-TCO Applications:
- Drug Delivery: Acts as a linker in the creation of prodrugs and ADCs, enhancing stability and targeted delivery.
- Bioconjugation: Attaches therapeutic agents, imaging probes, and biomolecules for diagnostics and therapeutic research.
How to Use:
- Storage: Keep at -20°C, away from light and moisture, for long-term stability.
- Solubility: Dissolves well in organic solvents like DMSO and methanol for chemical reactions.
m-PEG4-TCO is a versatile tool for pharmaceutical and biomedical research, supporting the development of innovative therapies and diagnostic technologies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.