m-PEG4 NHS Ester
m-PEG4 NHS Ester is a high-purity monofunctional PEG reagent containing an N-hydroxysuccinimide (NHS) ester for efficient amine coupling. The methoxy-capped PEG4 spacer improves solubility, reduces steric hindrance, and enhances biocompatibility, making it ideal for PEGylation of proteins, peptides, antibodies, and other amine-containing molecules. This reagent is widely used in bioconjugation, surface modification, and drug delivery research.
Key Features and Benefits:
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NHS Ester Reactivity: Forms stable amide bonds with primary amines under mild conditions.
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PEG4 Spacer: Enhances solubility, increases hydrophilicity, and reduces nonspecific interactions.
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Methoxy-Capped Terminus: Provides stability and prevents further reactivity, ensuring site-specific PEGylation.
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High Purity: Supplied at >95% purity for reproducible and reliable results.
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Biocompatible Design: Minimizes immunogenicity while improving pharmacokinetic properties.
Applications:
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Protein and Peptide PEGylation: Enhance solubility, stability, and circulation half-life of biomolecules.
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Antibody Modification: Conjugate PEG chains to antibodies for improved therapeutic profiles.
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Surface Functionalization: Modify nanoparticles, biosensors, or medical devices to reduce nonspecific binding.
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Drug Delivery Systems: Improve bioavailability and stability of therapeutic agents.
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Diagnostic Probe Development: PEGylate imaging agents for better in vivo performance.
Storage and Handling:
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Storage: Store at -20°C, protected from light and moisture.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to prevent NHS hydrolysis.
m-PEG4 NHS Ester offers efficient amine coupling, enhanced solubility, and high biocompatibility, making it an especially reliable choice for PEGylation and advanced bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
