m-PEG4-Benzaldehyde (CAS 153364-63-7) : Essential for Bioconjugation of Hydrazone and Oxime Bonds
Overview
m-PEG4-benzaldehyde is a versatile reagent for bioconjugation, featuring an aldehyde group attached to a PEG4 linker. It specifically reacts with aminooxy and hydrazide groups to form stable hydrazone and oxime bonds. This selective reactivity makes it perfect for precise protein labeling, crosslinking, and drug delivery applications.
Key Features
- Selective Reactivity: Forms hydrazone and oxime bonds with aminooxy and hydrazide groups.
- PEG4 Linker: Boosts solubility and reduces non-specific binding.
- Biocompatible: mPEG modification enhances compatibility in biological systems.
- Mild Conditions: Reacts efficiently under gentle conditions, preserving biomolecules.
Applications
- Bioconjugation and Labeling
- Labels proteins and peptides with hydrazone and oxime linkages.
- Modifies antibodies for diagnostics and targeted therapies.
- Crosslinks biomolecules for stable bioconjugates.
- Drug Delivery
- Enhances solubility in drug-polymer conjugates.
- Functionalizes nanoparticles for targeted delivery.
- Creates controlled release formulations.
- Surface and Material Modification
- Coats surfaces for biosensors and medical devices.
- Functionalizes hydrogels and nanomaterials for biomedical use.
Benefits
- Precise Bond Formation: Hydrazone and oxime bonds provide stable, specific bioconjugates.
- Versatile: Useful in bioconjugation, drug delivery, and material science.
- Enhanced Solubility: Efficient in aqueous and organic solvents.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.