Iodoacetamido-PEG6-acid is a PEG reagent containing an Iodoacetamide group and a carboxlic acid moiety. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
The iodoacetamide group is known for its ability to react with cysteine residues in proteins, forming stable covalent bonds via thioether linkage. This allows for the site-specific modification of proteins, enabling the attachment of various functional groups, such as fluorescent dyes, biotin, or other ligands. The PEG chain, on the other hand, provides water solubility, biocompatibility, and protection against immune recognition, making it a valuable tool in pharmaceutical research and development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
