Iodoacetamide-PEG3-Azide
This product is a heterobifunctional PEG3 linker containing an iodoacetamide group for thiol-selective alkylation and an azide group for bioorthogonal click chemistry. The PEG3 spacer adds hydrophilicity and flexibility, making this reagent especially ideal for dual-functional bioconjugation, probe development, and drug delivery applications.
Key Features and Benefits:
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Iodoacetamide Group: Reacts selectively with thiols to form stable thioether bonds.
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Azide Group: Enables CuAAC and SPAAC click chemistry with alkynes.
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PEG3 Spacer: Improves solubility and reduces steric hindrance for efficient reactions.
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Dual Reactivity: Combines thiol-specific and click chemistry handles.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications:
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Bioconjugation: Links thiol-containing biomolecules with azide-modified partners.
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Click Chemistry: Supports versatile labeling and probe construction.
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Drug Delivery: PEGylated scaffold improves stability, solubility, and bioavailability.
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Surface Modification: Functionalizes nanoparticles, polymers, and hydrogels.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture-free, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve azide and iodoacetamide stability.
This product provides thiol-specific alkylation with orthogonal click chemistry in a compact PEG3 framework, making it an especially versatile tool for protein modification, labeling, and advanced material design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
