Inosine (dI) Phosphoramidite (CAS: 141684-35-7) is a modified nucleoside used in oligonucleotide synthesis. Inosine, often referred to as a universal base, can pair with adenine, cytosine, or uracil, making it highly versatile in synthetic DNA sequences. This flexibility allows researchers to study DNA sequences with ambiguous base pairing or to reduce sequence-specific bias in experiments.
Applications:
- Oligonucleotide Synthesis: Incorporates inosine into DNA sequences to introduce flexible base pairing.
- Molecular Biology Research: Useful for studies involving degenerate sequences or reducing base-pairing specificity.
- Genetic Analysis: Enables creation of synthetic oligonucleotides with ambiguous base pairs for research and diagnostics.
Conclusion:
Inosine (dI) Phosphoramidite is essential for oligonucleotide synthesis, providing flexible base-pairing options in genetic research and diagnostic applications.
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