HO-PEG16-t-butyl ester
This product is a high-purity monofunctional PEG with a terminal hydroxyl and a tert-butyl ester linked by a PEG16 spacer. The hydroxyl enables versatile coupling reactions, while the acid-labile tert-butyl ester can be removed to yield a carboxylic acid. The PEG16 chain offers excellent hydrophilicity, extended reach, and flexibility for use in aqueous and organic systems.
Key Features
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Monofunctional PEG with terminal hydroxyl and t-butyl ester groups
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Selective t-butyl ester deprotection to generate carboxylic acid
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PEG16 spacer enhances solubility, hydrophilicity, and flexibility
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High chemical purity for reliable performance
Applications
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Synthesis of functional PEG derivatives
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Prodrug and polymer–drug conjugate development
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Biomolecule and surface modification
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Nanoparticle and material engineering requiring hydrophilic spacers
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Allow to reach room temperature before opening
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Avoid repeated freeze–thaw cycles
This product combines a reactive hydroxyl group with an acid-labile tert-butyl ester, linked by a PEG16 chain specifically for solubility, flexibility, and controlled conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
