Gly-Gly-Gly-PEG4-methyltetrazine (CAS: 2353409-82-0) is a small molecule designed for bioconjugation and imaging applications. It consists of a Glycine-Glycine-Glycine tripeptide, a PEG4 spacer, and a methyltetrazine group. The tripeptide sequence stabilizes the molecule and minimizes toxicity, while the PEG4 spacer improves solubility and stability. The methyltetrazine group, a reactive heterocyclic compound with two nitrogen atoms, acts as a handle for conjugating to biomolecules or imaging agents.
Key Features:
- Tripeptide (Gly-Gly-Gly): Stabilizes the molecule and reduces toxicity.
- PEG4 Spacer: Enhances solubility and stability, making it ideal for drug design.
- Methyltetrazine Group: Provides a highly reactive site for bioorthogonal conjugation, especially with TCO-modified molecules.
Applications:
- Bioconjugation: Links therapeutic agents, proteins, or imaging agents to delivery systems.
- Drug Design: The PEG4 spacer ensures drug solubility and stability in solution.
- Imaging: Facilitates the development of imaging probes for diagnostic purposes.
The combination of these functional groups makes Gly-Gly-Gly methyltetrazine a powerful tool in drug development, bioconjugation, and imaging technologies. It supports precise conjugation and improves the solubility and stability of linked molecules, expanding its use in biotechnology and pharmaceuticals.
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