FmocNH-PEG5-CH2CO2-NHS ester
FmocNH-PEG5-CH2CO2-NHS ester is a high-purity heterobifunctional PEG linker featuring an Fmoc-protected amine for orthogonal conjugation and an NHS ester for efficient amine coupling. The PEG5 spacer specifically improves solubility, enhances flexibility, and reduces steric hindrance, enabling high-yield bioconjugation in both aqueous and organic systems. The Fmoc group allows controlled deprotection for stepwise functionalization, making this reagent ideal for precision linker design in drug discovery, diagnostics, and advanced biomaterials.
Key Features and Benefits
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Fmoc-Protected Amine: Enables orthogonal, controlled deprotection for sequential conjugation.
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NHS Ester: Rapidly reacts with primary amines under mild conditions to form stable amide bonds.
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PEG5 Spacer: Enhances water solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports dual-step bioconjugation strategies.
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High Purity: >95% purity for consistent, reproducible performance.
Applications
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Stepwise Bioconjugation: Sequentially couple amines with precise control over reaction order.
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Peptide and Protein Modification: Add PEG linkers or functional handles via amine coupling.
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Nanoparticle Functionalization: Introduce orthogonal reactivity to particle surfaces.
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Drug Delivery Systems: Build linkers that enable targeted payload attachment and release.
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Diagnostic Probe Development: Create multifunctional imaging and biosensing agents.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve NHS ester reactivity.
FmocNH-PEG5-CH2CO2-NHS ester offers orthogonal reactivity with especially excellent solubility and stability, making it a versatile choice for constructing multifunctional bioconjugates, precision linkers, and targeted delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
