FmocNH-PEG5-CH2CO2-NHS ester is a polyethylene glycol (PEG)-based linker featuring an Fmoc-protected amine and an NHS ester functional group. The Fmoc group allows controlled deprotection, while the NHS ester efficiently reacts with primary amines, making it ideal for bioconjugation applications. The PEG5 spacer enhances water solubility and reduces steric hindrance in conjugation reactions.
Key Features:
✔ Bioconjugation-Ready: NHS ester reacts with primary amines for efficient conjugation.
✔ Fmoc Protection: Enables stepwise functionalization in peptide synthesis.
✔ Enhanced Solubility: PEG5 spacer improves solubility in aqueous and organic solvents.
✔ Versatile Linker: Useful in peptide modification, drug delivery, and PROTAC synthesis.
Applications:
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Peptide & Protein Modification: Facilitates site-specific labeling and crosslinking.
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PROTAC Synthesis: Used in targeted protein degradation research.
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Biomolecule Conjugation: Ideal for drug delivery systems and antibody-drug conjugates (ADCs).
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Surface Functionalization: Modification of nanoparticles and surfaces for biomedical applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
