Fmoc-Val-Cit-PAB-PNP
This product is a cleavable linker with an Fmoc-protected amine, Val-Cit dipeptide, PAB spacer, and PNP ester. The Val-Cit sequence enables cathepsin B–mediated release, while the PAB ensures payload liberation and the PNP ester supports efficient coupling.
Key Features and Benefits
-
Fmoc Group: Protects the amine for controlled, stepwise synthesis.
-
Val-Cit Dipeptide: Cleavable sequence recognized by cathepsin B.
-
PAB Spacer: Ensures efficient and self-immolative payload release.
-
PNP Ester: Reactive toward hydroxyls and amines for stable conjugation.
-
High Purity: Produced to ≥95% purity for reliable synthesis.
Applications
-
Antibody–Drug Conjugates (ADCs): Provides a protease-cleavable linker for targeted release.
-
Drug Delivery: Enables payload attachment with controlled intracellular release.
-
Probe Development: Builds cleavable imaging and diagnostic probes.
-
Peptide Synthesis: Functions as an Fmoc-protected dipeptide building block.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product integrates protease-cleavable functionality, orthogonal protection, and an activated ester handle, making it an especially valuable tool for ADC research and controlled bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
