Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used for antibody-drug conjugates (ADC). The Val-Cit can be specifically cleaved by cathepsin B enzyme. Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, and in various other pathological conditions. Cathepsin B has been proposed as a potentially effective biomarker for a variety of cancers. Overexpression of cathepsin B is correlated with invasive and metastatic cancers. As athepsin B enzyme only presents in the lysosome, the ADC payload can be site specifically released in the cell.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
