Fmoc-Val-Ala-PAB-OH
This product is a cleavable linker with a para-aminobenzyl (PAB) self-immolative spacer, and an Fmoc protecting group for orthogonal synthesis. This design specifically enables controlled payload release, making it valuable in ADC development, probe design, and drug delivery.
Key Features and Benefits:
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Fmoc Group: Acid-stable, base-labile protection for orthogonal synthesis.
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Val–Ala Dipeptide: Cleaved by intracellular proteases for selective release.
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PAB Spacer: Ensures complete, self-immolative drug liberation.
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Compact Structure: Supports efficient linker–payload integration.
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High Purity: Enables reproducibility in research and therapeutic applications.
Applications:
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ADC Linker Design: Core component for protease-cleavable antibody–drug conjugates.
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Drug Delivery: Facilitates selective release in tumor microenvironments.
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Probe Development: Builds cleavable imaging or diagnostic probes.
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Bioconjugation: Supports orthogonal multi-step conjugation strategies.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve functionality.
This product integrates orthogonal Fmoc protection, protease-cleavable Val–Ala, and a PAB spacer for drug release, making it a especially versatile building block for ADCs and advanced bioconjugates.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
