Fmoc-Ala-Ala-OH is a cleavable ADC linker, which is an Fmoc-protected alanine derivative that can be used in proteomic studies and solid-phase peptide synthesis techniques. For the synthesis of antibody-drug conjugates (ADCs), alanine is one of the simplest amino acids—with a methyl group as the side chain. This small side chain confers a high degree of flexibility (second only to glycine) when incorporated into polypeptide chains. The Fmoc group is usually removed with a base such as pyridine – an orthogonal deprotection strategy for the acid labile Boc group.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
