Fmoc-Val-Ala-OH (CAS: 150114-97-9) is a dipeptide composed of L-valine and L-alanine, with an N-terminal 9-fluorenylmethoxycarbonyl (Fmoc) protecting group. This compound is commonly used in solid-phase peptide synthesis (SPPS) and as a cleavable linker in antibody-drug conjugates (ADCs).
Key Features:
- Molecular Formula: C₂₃H₂₆N₂O₅
- Molecular Weight: 410.46 g/mol
- Appearance: White to off-white solid
- Melting Point: 217–219°C
- Solubility: Slightly soluble in DMF and DMSO
- Storage Conditions: Store at 2–8°C
Applications:
- Solid-Phase Peptide Synthesis (SPPS): Fmoc-Val-Ala-OH serves as a building block in SPPS, facilitating the assembly of peptides with specific sequences.
- Antibody-Drug Conjugates (ADCs): Utilized as a cleavable linker, it enables the attachment of cytotoxic drugs to antibodies, allowing for targeted cancer therapy.
Handling and Safety:
- Hazard Statements: May cause skin and eye irritation; may cause respiratory irritation.
- Precautionary Measures: Handle with appropriate protective equipment; avoid inhalation and contact with skin or eyes.
Fmoc-Val-Ala-OH is a valuable reagent in peptide synthesis and the development of targeted therapeutics, offering versatility in constructing complex biomolecules.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
