Fmoc-PEG2-NHS ester
This product is a PEG-based linker containing an Fmoc-protected amine, a PEG2 spacer, and an N-hydroxysuccinimide (NHS) ester. It enables efficient amine coupling through the NHS group while offering an orthogonal Fmoc-protected amine for controlled deprotection and further conjugation.
Key Features and Benefits
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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Fmoc-Protected Amine: Provides orthogonal reactivity after selective deprotection.
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PEG2 Spacer: Improves solubility and minimizes steric hindrance.
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Dual Functionality: Combines immediate amine coupling with protected amine chemistry.
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High Purity: Ensures reproducibility in synthetic and bioconjugation workflows.
Applications
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Bioconjugation: Links biomolecules via NHS ester chemistry and protected amine handles.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Constructs PEGylated scaffolds with orthogonal chemistry.
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Organic Synthesis: Serves as a versatile intermediate for modular linker design.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.
This product combines amine-reactive NHS chemistry with an Fmoc-protected amine in a PEG2 scaffold, specifically offering a compact and versatile linker for controlled multifunctional conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
