Fmoc-NH-PEG6-CH2COOH
This product is a heterobifunctional PEG linker featuring an Fmoc-protected amine, a six-unit PEG chain, and a terminal carboxymethyl group. The Fmoc group offers orthogonal protection for peptide synthesis, removable under mild base conditions, while the carboxyl reacts efficiently with amines or activated esters to form stable amide bonds. The PEG6 spacer provides solubility, flexibility, and medium-length spacing, making this reagent especially valuable for peptide chemistry, bioconjugation, and therapeutic design.
Key Features and Benefits
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Fmoc-Protected Amine: Stable during synthesis; removable with mild base.
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Carboxymethyl Group: Couples efficiently with amines for amide formation.
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PEG6 Spacer: Provides solubility, flexibility, and moderate spacing.
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Orthogonal Reactivity: Supports stepwise synthesis and multifunctional conjugation.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Peptide Synthesis: Introduces PEG units into peptides via SPPS.
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Bioconjugation: Couples proteins, antibodies, or probes through acid/amine chemistry.
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Drug Delivery: Serves as a PEGylated linker in therapeutic conjugates.
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Probe Development: Builds multifunctional probes with enhanced solubility.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect Fmoc under standard SPPS conditions; prepare fresh solutions.
This product integrates Fmoc-protected amine chemistry with a reactive carboxymethyl group on a PEG6 backbone, specifically offering flexibility for controlled synthesis and conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
