Fmoc-NH-PEG3-CH2COOH
This product is a heterobifunctional PEG linker with an Fmoc-protected amine on one end and a terminal carboxylic acid on the other, separated by a PEG3 spacer. It specifically enables stepwise peptide synthesis, amide coupling, and bioconjugation with enhanced solubility.
Key Features and Benefits
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Dual Functional Groups: Fmoc-protected amine allows controlled deprotection; terminal carboxyl enables amide bond formation.
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PEG3 Spacer: Improves aqueous solubility and provides moderate flexibility.
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Orthogonal Reactivity: Supports sequential conjugation strategies in synthesis.
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High Versatility: Useful in peptide modification, linker design, and biomolecule conjugation.
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High Purity: Ensures reproducibility in demanding bioconjugation workflows.
Applications
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Peptide Synthesis: Fmoc group supports controlled, stepwise solid-phase synthesis.
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Bioconjugation: Couples proteins, peptides, or polymers through amide linkage.
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Drug Delivery: Provides a PEG scaffold with orthogonal functional handles.
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Diagnostics: Functionalizes biomolecules for probe development and assays.
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Organic Synthesis: Serves as a modular intermediate in advanced linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates an Fmoc-protected amine and a carboxyl group through a PEG3 spacer, specifically providing orthogonal reactivity, solubility, and flexibility for peptide synthesis and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
