Fmoc-NH-PEG2-CH2COOH
This product is a heterobifunctional PEG linker containing an Fmoc-protected amine, a PEG2 spacer, and a terminal carboxylic acid. It specifically enables orthogonal protection, amide coupling, and conjugation, offering solubility and compact flexibility.
Key Features and Benefits
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Fmoc-Protected Amine: Allows selective deprotection for orthogonal conjugation strategies.
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Carboxylic Acid: Couples efficiently with amines to form stable amide bonds.
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PEG2 Spacer: Provides compact length and improves solubility.
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Dual Reactivity: Combines protected amine chemistry with carboxyl conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Links biomolecules through orthogonal amine and carboxyl chemistry.
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Probe Development: Builds multifunctional probes for diagnostics and research.
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Drug Delivery: Provides PEG scaffolds with staged reactive handles.
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Organic Synthesis: Serves as an intermediate for modular linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis or Fmoc removal.
This product integrates an Fmoc-protected amine with a carboxyl group in a PEG2 scaffold, specifically offering solubility, flexibility, and controlled reactivity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
