Fmoc-NH-PEG12-CH2COOH
This product is a heterobifunctional PEG linker containing an Fmoc-protected amine, a PEG12 spacer, and a terminal carboxymethyl group. The Fmoc group allows controlled deprotection under mild basic conditions, while the carboxyl couples efficiently with primary amines or activated esters. The PEG12 spacer provides excellent solubility, flexibility, and intermediate-length spacing, making this reagent especially valuable for peptide synthesis, bioconjugation, and therapeutic development.
Key Features and Benefits
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Fmoc-Protected Amine: Stable during synthesis, removable with mild base.
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Carboxymethyl Group: Couples efficiently with amines to form stable amide bonds.
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PEG12 Spacer: Provides long, flexible, hydrophilic spacing to reduce steric hindrance.
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Orthogonal Reactivity: Supports stepwise, controlled conjugation strategies.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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Peptide Synthesis: Incorporates PEG spacers into peptides by SPPS.
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Bioconjugation: Couples proteins, probes, and carriers via amine/acid chemistry.
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Drug Delivery: Functions as a PEGylated linker for therapeutic conjugates.
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Probe Development: Builds multifunctional PEGylated probes with extended solubility.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect Fmoc under standard SPPS conditions; prepare fresh solutions before use.
This product provides an orthogonally protected amine with a reactive carboxymethyl group on a PEG12 chain, specifically offering flexibility for peptide chemistry and advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
