Fmoc-NH-PEG11-CH2COOH
This product is a PEG linker containing an Fmoc-protected amine, a PEG11 spacer, and a terminal carboxymethyl group. It enables orthogonal amine deprotection and carboxyl coupling, specifically providing solubility, flexibility, and dual reactivity for bioconjugation and synthetic chemistry.
Key Features and Benefits
-
Fmoc-Protected Amine: Allows orthogonal protection with selective deprotection for controlled conjugation.
-
Carboxymethyl Group: Couples efficiently with amines to form stable amide bonds.
-
PEG11 Spacer: Provides moderate chain length, solubility, and biocompatibility.
-
Dual Reactivity: Combines protected amine functionality with reactive carboxyl chemistry.
-
High Purity: Ensures reproducibility in bioconjugation and synthesis workflows.
Applications
-
Bioconjugation: Links PEG chains to biomolecules with orthogonal control.
-
Probe Development: Builds multifunctional probes for imaging and diagnostics.
-
Drug Delivery: Provides PEG scaffolds with solubility and reactivity.
-
Organic Synthesis: Serves as an intermediate for modular linker design.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO to maintain stability.
This product integrates Fmoc-protected amine chemistry with a carboxymethyl group in a PEG11 scaffold, specifically offering versatile reactivity and solubility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
