Fmoc-NH-ethyl-SS-propionic NHS ester
This product is a heterobifunctional linker containing an Fmoc-protected amine, a reducible disulfide bond, a short alkyl chain, and an N-hydroxysuccinimide (NHS) ester. It enables amine coupling through the NHS group, while the Fmoc-protected amine can be deprotected for further conjugation, and the disulfide bond provides a cleavable linkage.
Key Features and Benefits
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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Fmoc-Protected Amine: Allows orthogonal reactivity after selective deprotection.
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Disulfide Bond: Enables reversible conjugation cleavable under reducing conditions.
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Compact Design: Provides efficient chemistry with minimal steric hindrance.
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High Purity: Ensures reproducible results in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links biomolecules with cleavable and orthogonal chemistries.
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Probe Development: Builds multifunctional probes with reversible linkages.
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Drug Delivery: Provides reducible scaffolds for controlled release.
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Organic Synthesis: Serves as a versatile intermediate for modular linker design.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid reducing agents before intended cleavage.
This product integrates NHS ester chemistry, a protected amine, and a cleavable disulfide bond in one compact scaffold, specifically offering a versatile tool for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.