Fmoc-NH-ethyl-SS-propionic NHS ester
This product is a heterobifunctional linker containing an Fmoc-protected amine, a reducible disulfide bond, a short alkyl chain, and an N-hydroxysuccinimide (NHS) ester. It enables amine coupling through the NHS group, while the Fmoc-protected amine can be deprotected for further conjugation, and the disulfide bond provides a cleavable linkage.
Key Features and Benefits
-
NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
-
Fmoc-Protected Amine: Allows orthogonal reactivity after selective deprotection.
-
Disulfide Bond: Enables reversible conjugation cleavable under reducing conditions.
-
Compact Design: Provides efficient chemistry with minimal steric hindrance.
-
High Purity: Ensures reproducible results in sensitive bioconjugation workflows.
Applications
-
Bioconjugation: Links biomolecules with cleavable and orthogonal chemistries.
-
Probe Development: Builds multifunctional probes with reversible linkages.
-
Drug Delivery: Provides reducible scaffolds for controlled release.
-
Organic Synthesis: Serves as a versatile intermediate for modular linker design.
Storage and Handling
-
Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid reducing agents before intended cleavage.
This product integrates NHS ester chemistry, a protected amine, and a cleavable disulfide bond in one compact scaffold, specifically offering a versatile tool for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
