Endo-BCN-PEG4-Val-Cit-PAB-MMAE: Advanced Cleavable ADC Linker with Potent MMAE Payload for Targeted Antibody-Drug Conjugates
Endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cutting-edge cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). This linker incorporates Val-Cit, which is specifically cleaved by cathepsin B, an enzyme that is exclusively present in lysosomes. This selective cleavage ensures that the potent MMAE payload is released only within the target cell. MMAE (monomethyl auristatin E) is a highly effective cytotoxic agent known for its ability to disrupt microtubule formation, leading to cell death. This advanced design maximizes the delivery and therapeutic efficacy of ADCs by ensuring targeted release and potent cytotoxic action.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
