endo-BCN-PEG2-PFP ester
This product is a heterobifunctional PEG linker featuring an endo-bicyclononyne (endo-BCN) group, a PEG2 spacer, and a pentafluorophenyl (PFP) ester. The BCN moiety enables rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides, while the PFP ester reacts efficiently with primary amines to form stable amide bonds. The PEG2 spacer improves solubility and reduces steric hindrance, making this reagent especially useful for bioconjugation and probe development.
Key Features and Benefits
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endo-BCN Group: Supports ultrafast copper-free click chemistry with azides under physiological conditions.
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PFP Ester: Highly reactive toward amines, forming stable amide linkages.
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PEG2 Spacer: Enhances solubility and reduces steric interference during conjugation.
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Dual Reactivity: Combines orthogonal SPAAC and amide bond formation for multifunctional applications.
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High Purity: Produced to ≥95% purity for consistent and reproducible results.
Applications
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Bioconjugation: Couples azide- and amine-functionalized biomolecules in a single linker system.
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Protein and Antibody Labeling: Enables orthogonal, site-specific modification strategies.
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Drug Delivery Research: Serves as a linker for constructing bioorthogonal carriers and ADC intermediates.
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Probe Development: Builds dual-reactive probes for imaging and diagnostic studies.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container, protected from light and moisture.
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Handling: Dissolve freshly before use; avoid repeated freeze–thaw cycles.
This product combines SPAAC click chemistry with highly reactive PFP ester functionality in a short PEG spacer, specifically offering a compact and versatile tool for bioconjugation and advanced chemical biology.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
