endo-BCN-PEG2-NHS ester
This product is a heterobifunctional linker featuring an endo-bicyclononyne (BCN) group for copper-free SPAAC click chemistry and an NHS ester for rapid amine coupling. The short PEG2 spacer provides solubility, compact spacing, and flexibility, making it especially useful for bioorthogonal labeling, probe development, and drug delivery.
Key Features and Benefits:
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Endo-BCN Group: Enables rapid, catalyst-free SPAAC click reactions with azides.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG2 Spacer: Improves solubility and minimizes steric hindrance.
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Dual Reactivity: Combines bioorthogonal and amine-targeted chemistry.
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High Purity: Ensures reliable and reproducible performance.
Applications:
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Bioorthogonal Labeling: Facilitates copper-free conjugation in vitro and in vivo.
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Probe Development: Builds BCN-modified probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds with balanced solubility.
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Bioconjugation: Supports dual-functional linker strategies in advanced workflows.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid hydrolysis of NHS ester.
This product integrates ultrafast SPAAC click chemistry with amine coupling in a PEG2 scaffold, specifically offering versatility for multifunctional conjugation and targeted delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
