endo-BCN-Carbamido-Pentylamine
This product is a bifunctional linker featuring a strained bicyclo[6.1.0]nonyne (BCN) group for copper-free click chemistry and a terminal primary amine. The carbamido-pentyl spacer enhances solubility and accessibility, making this reagent especially useful for orthogonal bioconjugation, drug delivery, and surface functionalization.
Key Features and Benefits:
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BCN Group: Enables strain-promoted azide–alkyne cycloaddition (SPAAC) without copper catalysts.
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Primary Amine: Couples with carboxyls, NHS esters, and other electrophiles.
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Carbamido-Pentyl Spacer: Improves solubility and reduces steric hindrance.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Orthogonal Reactivity: Combines click chemistry and amine coupling for multifunctional use.
Applications:
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Click Chemistry: Copper-free SPAAC conjugation with azides.
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Bioconjugation: Dual-functional linker for proteins, peptides, and small molecules.
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Drug Delivery: Useful in linker-payload systems for targeted therapeutics.
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Surface Modification: Functionalizes nanoparticles, hydrogels, and biomaterials.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain BCN reactivity.
This product provides a copper-free click handle with a reactive amine, making it an especially efficient linker for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
