endo-BCN-amido-Butanoic acid NHS ester
This product is a high-purity heterobifunctional linker with an endo-bicyclo[6.1.0]non-4-yne (endo-BCN) for rapid, copper-free SPAAC click chemistry and an NHS ester for efficient amine coupling. The butanoic acid amide spacer specifically provides optimal distance and flexibility, enhancing reactivity in both aqueous and organic systems. This reagent is especially ideal for orthogonal bioconjugation, site-specific labeling, and nanoparticle functionalization.
Key Features and Benefits
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Endo-BCN Group: Enables fast, catalyst-free SPAAC click chemistry with azides.
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NHS Ester: Reacts efficiently with primary amines to form stable amide bonds.
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Butanoic Acid Amide Spacer: Provides suitable spacing for improved conjugation efficiency.
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Heterobifunctional Design: Supports orthogonal, site-specific bioconjugations.
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High Purity: Supplied at >95% purity for reliable and reproducible results.
Applications
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Copper-free bioorthogonal labeling of azide-functionalized biomolecules.
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Protein, peptide, and antibody conjugation.
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Nanoparticle and polymer surface functionalization.
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Site-specific labeling in imaging and diagnostic assays.
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Development of targeted drug delivery systems.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve NHS ester reactivity.
This product combines copper-free click chemistry via BCN with amine coupling via NHS ester, linked by a butanoic acid spacer specifically for optimal solubility, flexibility, and conjugation efficiency.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
