DSPE-PEG8-Mal
This product is an amphiphilic conjugate consisting of a DSPE lipid anchor, an eight-unit PEG spacer, and a terminal maleimide group. The DSPE moiety stably incorporates into lipid bilayers, micelles, and liposomes, while the PEG8 chain improves hydrophilicity, flexibility, and steric stabilization. The maleimide group reacts selectively with thiols to form stable thioether bonds, making this reagent especially useful for liposome functionalization, nanomedicine, and targeted drug delivery.
Key Features and Benefits
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DSPE Lipid Anchor: Ensures stable insertion into liposomes, micelles, and membranes.
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PEG8 Spacer: Provides solubility, flexibility, and steric stabilization.
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Maleimide Group: Reacts selectively with thiols to form stable linkages.
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Amphiphilic Design: Combines lipid anchoring with thiol-reactive chemistry.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Drug Delivery: Functionalizes liposomes and nanoparticles for targeted therapy.
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Nanotechnology: Adds thiol-reactive groups to lipid-based assemblies.
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Bioconjugation: Couples thiol-modified biomolecules to lipid surfaces.
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Probe Development: Builds functional liposome–probe conjugates for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product integrates a lipid anchor with PEG8 solubility and maleimide thiol reactivity, specifically providing a versatile tool for nanomedicine and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
