DSG Crosslinker
This product is a homobifunctional, non-cleavable crosslinker featuring two NHS esters that efficiently couple primary amines. Its glutarate spacer provides moderate length and stability, making DSG especially useful for protein crosslinking, structural biology, and biochemical assay development.
Key Features and Benefits:
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Dual NHS Esters: React rapidly with primary amines under mild conditions.
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Non-cleavable Design: Provides stable, permanent crosslinks.
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Glutarate Spacer: Offers moderate linker length and flexibility.
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High Purity: Ensures reproducible results in sensitive workflows.
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Versatile Chemistry: Applicable in protein, peptide, and surface conjugation.
Applications:
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Protein Crosslinking: Stabilizes protein–protein interactions for structural studies.
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Structural Biology: Maps biomolecular complexes via covalent linkages.
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Bioconjugation: Couples amine-rich biomolecules in a controlled manner.
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Probe Development: Builds stable conjugates for imaging or diagnostic assays.
Storage and Handling:
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Storage: Store at –20 °C in a dry, moisture-free container.
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Handling: Dissolve freshly in anhydrous solvents (e.g., DMSO) before use; avoid hydrolysis of NHS esters.
This product provides reliable, stable amine-to-amine conjugation through a non-cleavable glutarate spacer, making it an essential tool specifically for crosslinking studies and bioconjugation research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
